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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Cardiac myocytes produce these hormones in response to ventricular stretching...
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Rahmah Ikhlas1, Neda Rashidi-Ranjbar2, Nathan W Churchill2

  • 1Keenan Research Centre for Biomedical Science, LKSI, St. Michaels Hospital, Toronto, Canada, Toronto, ON, Canada.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Neuropsychiatric symptoms in Alzheimer's Disease are linked to specific blood biomarkers like pTAU181, NFL, and GFAP. These markers may help understand and monitor symptom severity in AD patients.

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Area of Science:

  • Neuroscience
  • Biomarkers
  • Neurodegenerative Diseases

Background:

  • Neuropsychiatric Symptoms (NPS) significantly worsen Alzheimer's Disease (AD) burden and reduce patient quality of life.
  • Understanding the factors contributing to NPS is crucial for effective AD management.
  • This study investigates the relationship between NPS and key blood-based biomarkers in AD.

Purpose of the Study:

  • To explore the association between the severity of NPS and specific blood-based biomarkers in individuals with AD or Mild Cognitive Impairment (MCI).
  • To identify potential blood biomarkers that correlate with NPS domains, aiding in understanding disease mechanisms.
  • To assess the utility of biomarkers like GFAP, NFL, pTAU181, AB40, and AB42 in relation to NPS.

Main Methods:

  • Utilized data from 107 participants (diagnosed with AD or MCI) from the Ontario Neurodegenerative Disease Research Initiative (ONDRI) database.
  • Measured plasma levels of Glial Fibrillary Acidic Protein (GFAP), Neurofilament Light Chain (NFL), Amyloid Beta 40 (AB40), Amyloid Beta 42 (AB42), and Phosphorylated Tau at Threonine 181 (pTAU181).
  • Conducted partial Spearman correlations, adjusting for age, sex, and education, with a False Discovery Rate (FDR) threshold of 0.05.

Main Results:

  • Significant positive correlations were found between apathy and pTAU181 (Rs=0.27) and NFL (Rs=0.30).
  • Anxiety scores correlated positively with GFAP (Rs=0.28) and NFL (Rs=0.33).
  • GFAP also showed significant positive correlations with appetite, motor function, and total NPS severity scores.

Conclusions:

  • Blood-based biomarkers pTAU181, NFL, and GFAP are associated with the development of NPS in Alzheimer's Disease.
  • These biomarkers may offer insights into the underlying mechanisms of NPS and serve as potential monitoring tools.
  • Further research in larger cohorts and longitudinal studies is necessary to confirm these associations and explore causality.