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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

MayaRae N Mugosa1, Jefferson W Kinney2, Lorenzo Gabriel Pasia3

  • 1UNLV, Las Vegas, NV, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

This study explored blood biomarkers for Alzheimer's disease (AD) progression. While not statistically significant, trends suggest phosphorylated tau-217 (pTau217) may be a valuable biomarker for tracking AD.

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Area of Science:

  • Biochemistry
  • Neuroscience
  • Biomarker Discovery

Background:

  • Alzheimer's disease (AD) is a progressive neurodegenerative condition impacting cognition and daily function.
  • Early diagnosis and monitoring of AD progression are vital for effective management.
  • Current AD diagnostic tools are often invasive and costly; blood biomarkers offer a scalable alternative.

Purpose of the Study:

  • To evaluate plasma concentrations of glial fibrillary acidic protein (GFAP), phosphorylated tau-181 (ptau181), and phosphorylated tau-217 (pTau217).
  • To assess the potential of these biomarkers in tracking Alzheimer's disease progression over two years.

Main Methods:

  • Plasma concentrations of GFAP and ptau181 were measured using the SIMOA Quanterix instrument.
  • Plasma concentrations of pTau217 were measured using chemiluminescent enzyme immunoassay (CLEIA) on the Lumipulse G1200 platform.
  • Longitudinal analysis was performed to identify trends in biomarker concentrations over time.

Main Results:

  • Longitudinal analysis indicated a gradual increase in concentrations for some candidate biomarkers over two years.
  • No statistically significant differences in biomarker levels were observed between disease states during the study period.
  • Trends suggest potential utility, though larger sample sizes are needed for statistical validation.

Conclusions:

  • The observed trends in biomarker concentrations warrant further investigation with larger cohorts.
  • Phosphorylated tau-217 (pTau217) shows promise as a biomarker for Alzheimer's disease progression due to its correlation with amyloid status.
  • Continued research into pTau217 is recommended for its potential in AD diagnostics and monitoring.