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Clinical Manifestations.

Sophie M van der Landen1,2, Sietske A M Sikkes1,2,3, Casper de Boer1,2

  • 1Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, Netherlands.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

The web-based cognitive assessment, cCOG, demonstrates good test-retest reliability for remote monitoring of cognitive function in individuals at risk of dementia. This supports its use in large-scale disease surveillance.

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Area of Science:

  • Neuroscience
  • Psychometrics
  • Digital Health

Background:

  • Web-based cognitive assessments are crucial for remote disease monitoring.
  • Mild cognitive impairment (MCI) and dementia require accurate and timely detection.
  • Test-retest reliability is a key psychometric property for cognitive assessments.

Purpose of the Study:

  • To evaluate the test-retest reliability of the cCOG assessment.
  • To determine the suitability of cCOG for remote cognitive assessment in a population at risk of dementia.

Main Methods:

  • 250 participants at risk of dementia completed cCOG remotely at baseline and after one month.
  • Global Cognitive Score (GCS) was calculated from five subtests.
  • Intraclass Correlation Coefficient (ICC) was used to assess test-retest reliability.
  • Analyses were stratified by device type, age, sex, and education.

Main Results:

  • High completion rates (94.8% at baseline, 94.0% at one month).
  • Good test-retest reliability for the GCS with an ICC of 0.75.
  • Comparable reliability across different demographic subgroups and device types.

Conclusions:

  • cCOG shows reliable performance for remote cognitive assessment in a population at risk for dementia.
  • Findings support the use of cCOG for large-scale monitoring and early detection of cognitive decline.
  • Further research should investigate factors influencing test completion and outliers in remote settings.