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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
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Clinical Manifestations.

Ravinder Singh1, Pratima Singh1, Suruchi Chaubey1

  • 1Chitkara University, Rajpura, Punjab, India.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Metabolomics reveals distinct amino acid profiles in Alzheimer's disease (AD). Lower levels of key amino acids and higher glycine/aspartate correlate with cognitive decline, suggesting potential biomarkers and therapeutic targets for AD.

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Area of Science:

  • Neuroscience
  • Metabolomics
  • Biochemistry

Background:

  • Neurodegenerative diseases like Alzheimer's disease (AD) involve complex metabolic alterations.
  • Metabolomics offers a powerful approach to understanding these changes.
  • This study focuses on amino acid metabolism in AD patients.

Purpose of the Study:

  • To investigate metabolic variations in amino acid profiles between AD patients and healthy controls.
  • To explore the relationship between altered amino acid levels and cognitive function decline in AD.
  • To identify potential metabolic biomarkers for AD diagnosis and treatment.

Main Methods:

  • Gas chromatography-mass spectrometry (GC-MS) was employed to analyze plasma amino acid metabolites.
  • 120 participants were divided into AD patients and healthy control groups.
  • Neuropsychological tests assessed memory, executive function, processing speed, and attention.

Main Results:

  • AD patients exhibited significantly lower levels of tryptophan, methionine, phenylalanine, and tyrosine compared to controls.
  • Conversely, AD patients showed elevated levels of aspartate and glycine.
  • These amino acid alterations were associated with cognitive impairments, including memory loss and slowed processing speed.

Conclusions:

  • Alzheimer's disease is characterized by specific amino acid disturbances, including decreased phenylalanine, tyrosine, methionine, and tryptophan, and increased glycine and aspartate.
  • These metabolic changes are linked to cognitive deterioration, indicating their potential as AD biomarkers.
  • Amino acid supplementation may represent a therapeutic strategy to mitigate cognitive decline in AD.