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Clinical Manifestations.

Mark A Bernard1,2,3, Arjun V Masurkar1,2,4,5

  • 1NYU Grossman School of Medicine, New York, NY, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Neighborhood deprivation is linked to excessive daytime sleepiness (EDS) in older adults without subjective cognitive decline (SCD), a preclinical stage of Alzheimer's disease (AD). The association was not significant in those with SCD, suggesting complex interactions.

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Area of Science:

  • Neuroscience
  • Public Health
  • Gerontology

Background:

  • Subjective cognitive decline (SCD) is an early indicator of Alzheimer's disease (AD).
  • Excessive daytime sleepiness (EDS) is a risk factor for AD and may be influenced by neighborhood deprivation.
  • Social determinants of health, like neighborhood deprivation, can impact sleep and cognitive health.

Purpose of the Study:

  • To investigate the association between neighborhood deprivation and EDS in cognitively normal older adults.
  • To determine if this association differs based on the presence or absence of SCD.
  • To explore the role of social determinants of health in preclinical AD.

Main Methods:

  • Study included 81 cognitively normal older adults (mean age 73.9).
  • SCD assessed via Global Deterioration Scale; EDS via Epworth Sleepiness Scale (ESS).
  • Neighborhood deprivation measured by Area Deprivation Index (ADI); analyzed using multivariate linear regression.

Main Results:

  • A significant association was found between ADI and ESS in the overall cohort (p=0.007).
  • This association persisted in participants without SCD (p=0.007).
  • No significant association between ADI and ESS was observed in participants with SCD (p=0.178).

Conclusions:

  • The effect of neighborhood deprivation on sleepiness is dependent on SCD status.
  • Findings suggest a nuanced relationship between socioeconomic factors, sleep, and preclinical AD.
  • Further research is needed to understand how neighborhood disadvantage affects sleep pathophysiology in individuals with SCD.