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Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

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Frequency-Dependent Diffusion-Relaxation Distribution MRI: Scan-Rescan Reproducibility Ex Vivo and Caveats.

Pak Shing Kenneth Or^1,2, Maxime Yon^2,3,4, Omar Narvaez⁴

¹Multiscale Imaging and Integrative Biophysics Unit, National Institute on Aging, NIH, Baltimore, Maryland, USA.

NMR in Biomedicine

|December 26, 2025

Summary

This summary is machine-generated.

Frequency-dependent multidimensional MRI (ω MD-MRI) shows high reproducibility in ex vivo mouse brains. Preclinical micro-imaging benefits from advanced hardware, though fixation time may introduce bias in some metrics.

Keywords:

diffusion MRI frequency‐dependent diffusion multidimensional MRI oscillating gradients (OGSE)reproducibility tensor valued diffusion encoding

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Area of Science:

Biomedical Imaging
Neuroscience
Magnetic Resonance Imaging

Background:

Frequency-dependent diffusion-relaxation distribution MRI offers advanced microstructural tissue characterization beyond traditional methods.
Reproducibility of ω MD-MRI is established clinically but requires evaluation in preclinical settings with enhanced hardware.

Purpose of the Study:

To investigate the reproducibility of ω MD-MRI in ex vivo mouse brains using a micro-imaging system.
To assess the impact of preclinical hardware and fixation time on ω MD-MRI metrics.

Main Methods:

Utilized a micro-imaging system for ex vivo mouse brain analysis.
Acquired and analyzed frequency-dependent multidimensional MRI data.
Compared scan-rescan reproducibility and evaluated fixation time effects.

Main Results:

High reproducibility was observed for estimated signal fractions of intra-voxel spectral components (white and gray matter) and frequency-dependent parameters.
Scan-rescan bias was identified in certain metrics, attributed to fixation time effects.
Preclinical setup with improved gradient hardware enhanced the reproducibility of diffusion frequency-dependent metrics compared to in vivo clinical data.

Conclusions:

ω MD-MRI demonstrates high reproducibility in preclinical ex vivo mouse brain studies.
Fixation time is a critical factor influencing reproducibility and requires careful consideration.
Advanced preclinical hardware significantly benefits the reproducibility of diffusion frequency-dependent MRI metrics.