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Clinical Manifestations.

Dolly Reyes-Dumeyer1,2,3, Guerry M Peavy4, Namkhue Vo5

  • 1G. H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.

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|December 26, 2025
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Summary
This summary is machine-generated.

Rigorous training and quality assurance are vital for the Asian Cohort for Alzheimer's Disease (ACAD) study. This approach ensures accurate data collection and reliable findings in diverse populations for Alzheimer's disease research.

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Area of Science:

  • Neuroscience
  • Epidemiology
  • Gerontology

Background:

  • The Asian Cohort for Alzheimer's Disease (ACAD) is a large, multi-site study investigating genetic and lifestyle risk factors for Alzheimer's disease (AD) in diverse Asian populations.
  • Challenges in training and quality assurance (TQA) were identified due to the multilingual and multicultural nature of the ACAD cohort.
  • A TQA core was established to develop and implement effective training and quality control measures.

Purpose of the Study:

  • To establish standardized training protocols and quality assurance procedures for the ACAD study.
  • To address the unique TQA challenges presented by a multilingual and multicultural cohort.
  • To ensure data quality and integrity for reliable Alzheimer's disease research.

Main Methods:

  • Developed a comprehensive, role-specific training protocol with materials in multiple languages (English, Mandarin, Cantonese, Vietnamese, Korean).
  • Implemented quality assurance procedures including knowledge-based quizzes for certification, double scoring, and re-certification.
  • Utilized an all-hands Case Diagnosis and Education Meeting (ACADEME) for case review and discussion of challenging experiences.

Main Results:

  • Achieved significant improvements in quiz scores across all training modules, demonstrating enhanced knowledge retention (p < 0.001 for most).
  • Reported training completion rates varied by role, with prescreening and outreach at 74% and data management at 57%.
  • Highlighted challenges in developing detailed multilingual materials and effective communication strategies for consistent data accuracy.

Conclusions:

  • The ACAD study emphasizes the critical role of rigorous training and quality assurance in large-scale dementia cohort studies.
  • Standardized data collection and integrity are paramount for generating meaningful and reproducible scientific outcomes in AD research.
  • The TQA strategies employed by ACAD offer valuable insights for similar multilingual and multicultural research initiatives.