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Drug Development.

Megan G Witbracht1, Thuy V Lu2, Dan Hoang3

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|December 26, 2025
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Summary
This summary is machine-generated.

Mailed postcards were more effective than social media ads for recruiting diverse participants into Alzheimer's disease research registries. Postcards enrolled more people equally across neighborhood disadvantage levels, promoting inclusion in AD research.

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Area of Science:

  • Neuroscience
  • Public Health
  • Clinical Research

Background:

  • Underrepresentation of diverse populations in Alzheimer's disease (AD) research is a significant challenge.
  • Recruitment registries can enhance diversity and inclusion in AD research.
  • The Area Deprivation Index (ADI) correlates with neighborhood health and brain health outcomes.

Purpose of the Study:

  • To evaluate recruitment strategies for diverse neighborhoods using the ADI.
  • To assess the effectiveness of social media and mailed postcards for the UC Irvine Consent-to-Contact (UCI C2C) registry.

Main Methods:

  • An interrupted time series experiment compared social media ads and mailed postcards.
  • Interventions were deployed across ADI quintiles in Orange County, CA.
  • Chi-squared tests analyzed enrollment differences by ADI for each recruitment method.

Main Results:

  • Postcards enrolled 113 participants (0.1% response rate) with no ADI-based difference.
  • Social media ads enrolled 74 participants (0.01% response rate) with higher enrollment from less deprived areas.
  • Postcards demonstrated equitable recruitment across ADI levels, while social media did not.

Conclusions:

  • Mailed postcards are more effective than social media advertisements for recruiting diverse individuals into AD research registries.
  • Postcards achieved equitable enrollment across varying levels of neighborhood disadvantage.
  • This strategy enhances diversity and inclusion in Alzheimer's disease research.