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Clinical Manifestations.

Paul W H Brewster1, Diane M Jacobs2, Nicole D Anderson3,4

  • 1University of Victoria, Victoria, BC, Canada.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Digital cognitive assessments in the Brain Health Support Program showed similar baseline results to traditional methods but revealed subtle improvements and lifestyle associations over time. These findings support digital tools for dementia risk reduction studies.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Digital Health

Background:

  • The CAN-THUMBS-UP Brain Health Support Program (BHP) is a year-long web-based study focused on dementia risk reduction.
  • It incorporated two digital cognitive assessments: Cogniciti's Brain Health Assessment (BHA) and smartphone-based MyCogHealth.
  • These were compared against a traditional neuropsychological battery (NTB) for exploratory outcomes.

Purpose of the Study:

  • To compare novel digital cognitive assessment approaches (BHA, MyCogHealth) with a traditional neuropsychological battery (NTB).
  • To investigate baseline associations and longitudinal changes in cognition using different assessment frequencies.
  • To explore cognition-lifestyle associations within a dementia risk reduction framework.

Main Methods:

  • Mixed models for repeated measures (MMRM) analyzed global composites from NTB, BHA, and MyCogHealth, adjusting for age, sex, education, and cognitive status.
  • Structural equation modeling (dual-growth models) investigated coupled changes between cognition (BHA, MyCogHealth) and lifestyle.
  • Lifestyle composite and time were modeled as time-varying covariates.

Main Results:

  • Baseline cognition was significantly associated with age, education, and cognitive status across all measurement approaches.
  • While the BHA remained stable, MyCogHealth showed significant improvement over time, influenced by age and education.
  • The lifestyle composite was associated with MyCogHealth intercept and improvement, but no coupled changes in their rates of change were observed.

Conclusions:

  • Digital cognitive assessments demonstrated comparable baseline associations to the NTB.
  • Increased measurement frequency with digital tools revealed subtle cognitive improvements and cognition-lifestyle links missed by traditional methods.
  • Digital assessments are viable, flexible alternatives for cognitive endpoints in lifestyle-based dementia risk reduction research.