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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Ying Luan1, Ying Cui1, Jie Wang2

  • 1Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Impaired glymphatic function, measured by the Diffusion Tensor Image Analysis along the Perivascular Space (DTI ALPS) index, is linked to increased tau spread and faster cognitive decline in Alzheimer's disease. This suggests the glymphatic system is crucial for clearing tau pathology.

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Area of Science:

  • Neuroscience
  • Neuroimaging
  • Gerontology

Background:

  • Tau protein aggregation and spread are key features of Alzheimer's disease (AD).
  • The glymphatic system, responsible for brain waste clearance, may influence tau pathology.
  • The role of glymphatic function in inter-neuronal tau propagation is not well understood.

Purpose of the Study:

  • To investigate the association between glymphatic system function and tau pathology spread.
  • To determine if glymphatic function impacts cognitive decline and clinical progression in Alzheimer's disease.

Main Methods:

  • Utilized data from 173 ADNI and 303 CPAS participants with MRI, PET, DTI, and cognitive assessments.
  • Calculated the Diffusion Tensor Image Analysis along the Perivascular Space (DTI ALPS) index to assess glymphatic function.
  • Analyzed tau-PET SUVRs, functional connectivity, and their relationship with ALPS index and cognitive decline.

Main Results:

  • Lower ALPS index (impaired glymphatic function) correlated with higher connectivity-based tau accumulation.
  • Reduced ALPS was associated with poorer baseline cognition and accelerated cognitive decline.
  • Individuals with lower ALPS and higher tau accumulation showed faster clinical progression.

Conclusions:

  • Impaired glymphatic system function may exacerbate tau pathology spread and accelerate cognitive decline in Alzheimer's disease.
  • These findings highlight the glymphatic system's role in tau clearance and suggest it as a therapeutic target for AD.