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Clinical Manifestations.

Vidhya R1, Gauri Mullerpattan1, Abhishek Mensegere Lingegodwa1

  • 1Centre for Brain Research, Indian Institute of Science, Bangalore, Karnataka, India.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

A family history of conditions like memory issues, stroke, and cardiac illness may impact cognitive performance. This study found attention scores differed significantly in individuals with a family history of memory problems.

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Area of Science:

  • Neurology
  • Genetics
  • Public Health

Background:

  • Family history of dementia is a known risk factor for cognitive decline.
  • Clinical conditions like hypertension, diabetes, and stroke are linked to impaired cognition.
  • Limited research exists on the impact of familial history of these conditions on cognitive function.

Purpose of the Study:

  • To investigate the association between familial history of clinical conditions and cognitive performance.
  • To explore potential genetic influences on cognitive functioning.

Main Methods:

  • Cross-sectional study of 1665 non-demented participants (aged 45+) from the TATA Longitudinal Study of Aging.
  • Collected data on family history of various clinical conditions and cognitive assessments (ACE-III, COGNITO Battery).
  • Utilized descriptive statistics, Chi-square test, and regression analysis for data interpretation.

Main Results:

  • Prevalence of family history: 17.7% memory impairment, 60.9% cardiac illness, 59.4% stroke.
  • Significant difference in family history of memory issues between age groups (p=0.012).
  • Attention scores differed significantly between individuals with and without a family history of memory issues (p=0.036).

Conclusions:

  • Family history of memory issues is associated with variations in attention scores.
  • Suggests potential genetic factors influencing early cognitive performance.
  • Highlights the need for further research to identify early risk markers for cognitive impairment.