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Published on: September 20, 2018
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Clinical Manifestations
Vidhya R1, Gauri Mullerpattan1, Abhishek Mensegere Lingegodwa1
1Centre for Brain Research, Indian Institute of Science, Bangalore, Karnataka, India.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
Summary
A family history of conditions like memory issues, stroke, and cardiac illness may impact cognitive performance. This study found attention scores differed significantly in individuals with a family history of memory problems.
Area of Science:
- Neurology
- Genetics
- Public Health
Background:
- Family history of dementia is a known risk factor for cognitive decline.
- Clinical conditions like hypertension, diabetes, and stroke are linked to impaired cognition.
- Limited research exists on the impact of familial history of these conditions on cognitive function.
Purpose of the Study:
- To investigate the association between familial history of clinical conditions and cognitive performance.
- To explore potential genetic influences on cognitive functioning.
Main Methods:
- Cross-sectional study of 1665 non-demented participants (aged 45+) from the TATA Longitudinal Study of Aging.
- Collected data on family history of various clinical conditions and cognitive assessments (ACE-III, COGNITO Battery).
- Utilized descriptive statistics, Chi-square test, and regression analysis for data interpretation.
Main Results:
- Prevalence of family history: 17.7% memory impairment, 60.9% cardiac illness, 59.4% stroke.
- Significant difference in family history of memory issues between age groups (p=0.012).
- Attention scores differed significantly between individuals with and without a family history of memory issues (p=0.036).
Conclusions:
- Family history of memory issues is associated with variations in attention scores.
- Suggests potential genetic factors influencing early cognitive performance.
- Highlights the need for further research to identify early risk markers for cognitive impairment.
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