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Clinical Manifestations.

Meaghan Am McKenna1, Charlotte B Curnin1, John Torous1

  • 1Beth Israel Deaconess Medical Center, Boston, MA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
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Summary
This summary is machine-generated.

A new online cognitive test, D-Cog, shows promise for at-home Alzheimer's disease monitoring. This tool can detect cognitive changes, aiding early diagnosis of conditions like delirium or ARIA.

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Area of Science:

  • Neurology
  • Gerontology
  • Digital Health

Background:

  • Early Alzheimer's Disease (AD) patients experience cognitive fluctuations.
  • Changes can signal serious conditions like delirium or ARIA from amyloid-reducing therapy.
  • Current tools lack frequent at-home cognitive assessment capabilities.

Purpose of the Study:

  • Investigate the utility, convenience, and feasibility of a novel online cognitive assessment (D-Cog) for at-home use.
  • Assess D-Cog's potential for detecting cognitive changes in AD patients.
  • Evaluate D-Cog as a tool for early detection of delirium or ARIA.

Main Methods:

  • Developed D-Cog, a brief (<2 min) online cognitive test designed as a "cognitive vital sign."
  • Collected pilot data from 82 patients with MCI or AD.
  • Recruited 15 participants for a 6-month daily home D-Cog assessment with remote monitoring.

Main Results:

  • 54 participants (mean age 76) completed the study, averaging a D-Cog score of 3.9.
  • D-Cog scores correlated highly with Mini-Mental State Examination (MMSE) scores (r=0.56, p=1.3e-5).
  • Patients reported D-Cog as easy to complete at home.

Conclusions:

  • The D-Cog assessment is feasible for clinical practice and remote at-home use by AD patients.
  • D-Cog scores show good correlation with traditional neuropsychological tests.
  • D-Cog shows promise for frequent, convenient at-home monitoring and early detection of cognitive changes.