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Biomarkers.

Jake A Galler1, Liuqing Yang2, Chao-Yi Wu1

  • 1Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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Summary

The MIND GamePack effectively distinguishes cognitively normal individuals from those with cognitive impairment using gameplay data. This digital tool shows promise for cognitive assessment and tracking changes over time.

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Area of Science:

  • Neuroscience
  • Digital Health
  • Cognitive Science

Background:

  • Traditional neuropsychological assessments face challenges in frequent measurement and in-home compliance.
  • Cognitively impaired individuals may find standard assessments tiresome.
  • Digital adaptations often struggle with reliability and participant engagement.

Purpose of the Study:

  • To evaluate the effectiveness of the MIND GamePack, a gamified tablet-based cognitive assessment tool.
  • To determine if gameplay features can differentiate between cognitively normal and impaired individuals.
  • To validate digital biomarkers against standard neuropsychological tests.

Main Methods:

  • Sixty participants (cognitively normal and impaired) played four iPadOS games for two weeks.
  • Ten gameplay features were analyzed to compare cognitive groups.
  • Spearman's correlation assessed the relationship between digital biomarkers and standard tests (RBANS, TMT).

Main Results:

  • Nine out of ten features successfully differentiated cognitively normal from impaired participants.
  • Gameplay features showed significant correlations with memory, language, and executive function measures.
  • Specifically, Percent Accuracy correlated with memory indices, and Number of Hard Drops correlated with executive function tests.

Conclusions:

  • The MIND GamePack demonstrates effectiveness in identifying cognitive status differences.
  • Digital biomarkers derived from gamified assessments can reflect memory, language, and executive function.
  • Gamified assessments offer a promising approach for clinical trials, screening, and monitoring cognitive health.