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Clinical Manifestations.

Kristin Harkins1, Jason Karlawish1, Kyra O'Brien1

  • 1University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Clinicians disclosing Alzheimer's disease (AD) amyloid PET results in ADNI-4 reported high confidence and adequate participant understanding. The study highlights effective disclosure practices for future research and clinical care.

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Area of Science:

  • Neurology
  • Neuroimaging
  • Biomarker Disclosure

Background:

  • Previous research focused on patient experiences with Alzheimer's disease (AD) biomarker disclosure.
  • The experiences of clinicians disclosing AD biomarkers remain under-characterized.

Purpose of the Study:

  • To examine the clinician experience of disclosing amyloid positron emission tomography (PET) results.
  • To inform future disclosure practices in AD research and care.

Main Methods:

  • The study involved clinicians disclosing amyloid PET results in the ADNI-4 longitudinal cohort study.
  • Disclosing clinicians completed questionnaires post-disclosure, reporting on visit length, understanding, emotional reactions, topics, challenges, and overall assessment.

Main Results:

  • Clinicians reported high confidence (70-77%) in managing disclosure and answering questions.
  • Participant and study partner understanding was rated as adequate in most cases (94% for participants).
  • Disclosure visits averaged 29.4 minutes, with discussions focusing on the result's meaning (99%) and emotional impact (49%).

Conclusions:

  • Clinicians in the ADNI-4 study expressed high confidence and perceived adequate understanding among participants and study partners.
  • Challenges during disclosure were infrequent, with most visits rated as good or excellent.
  • These findings, combined with participant data, will guide future amyloid PET result disclosure in research and clinical settings.