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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Cardiac myocytes produce these hormones in response to ventricular stretching...
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Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Gaigai Lu1, Xiang Fan1, Keyan Yu1

  • 1Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Small VCP Interacting Protein (SVIP) shows promise as a blood biomarker for Mild Cognitive Impairment (MCI). Plasma SVIP levels were significantly lower in MCI patients, outperforming Valosin-Containing Protein (VCP) in detection.

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Biomarker Discovery

Background:

  • Mild Cognitive Impairment (MCI) is an early indicator of Alzheimer's Disease (AD).
  • Current AD blood biomarkers like p-tau have low concentrations.
  • Valosin-Containing Protein (VCP) influences tau levels, but its blood diagnostic utility is unknown, potentially limited by its large size.

Purpose of the Study:

  • To investigate the diagnostic performance of plasma Small VCP Interacting Protein (SVIP) for MCI.
  • To compare SVIP's efficacy against Valosin-Containing Protein (VCP) as a blood-based biomarker for MCI.

Main Methods:

  • Eighty-four participants (44 cognitively unimpaired, 40 MCI) from the STAR cohort were analyzed.
  • Plasma SVIP and VCP levels were quantified using deep plasma proteomics.
  • Receiver operating characteristic (ROC) analysis evaluated diagnostic performance.

Main Results:

  • MCI patients exhibited significantly decreased plasma SVIP levels compared to controls (p < 0.001).
  • No significant difference in plasma VCP levels was found between MCI and control groups (p = 0.823).
  • SVIP demonstrated a high diagnostic accuracy for MCI with an AUC of 0.836, while VCP's AUC was 0.513.

Conclusions:

  • Plasma SVIP is a potential blood-based biomarker for detecting MCI.
  • Valosin-Containing Protein (VCP) is unlikely to be an effective blood biomarker for MCI, possibly due to its large molecular size.