Related Experiment Video
Updated: Jan 7, 2026
05:10
Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
10.1K
Drug Development.
1Federal University Wukari, Wukari, Taraba, Nigeria.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
Summary
Olanzapine (OLN) significantly improved memory and reduced oxidative stress in mice with aluminum chloride-induced impairment. This study highlights OLN
Area of Science:
- Neuroscience
- Pharmacology
- Toxicology
Background:
- Chronic kidney disease (CKD) is linked to cognitive decline and dementia.
- Aluminum chloride (AlCl₃) induces memory impairment and oxidative stress.
- Olanzapine (OLN) exhibits neuroprotective and antioxidant properties.
Purpose of the Study:
- To evaluate the effects of OLN on cognitive function in AlCl₃-induced memory impairment.
- To assess OLN's impact on oxidative stress and brain cytokines.
- To investigate the relationship between brain and kidney markers.
Main Methods:
- Male mice were divided into five groups: control, AlCl₃, AlCl₃ + OLN (two doses), and AlCl₃ + Donepezil.
- Treatments were administered orally for seven days.
- Neurobehavioral tests (Y maze, open field), biochemical analyses (TNF-α, oxidative stress markers, urea, protein), and histopathology were performed.
Main Results:
- OLN significantly improved cognitive function and reduced oxidative stress markers.
- OLN decreased brain tumor necrosis factor-alpha (TNF-α) levels and neurodegeneration.
- OLN showed limited effects on kidney urea and protein levels.
Conclusions:
- OLN demonstrates significant memory-enhancing and antioxidant effects.
- OLN reduces pro-inflammatory cytokine levels in the brain.
- OLN's impact on kidney function appears minimal, but the brain-kidney axis warrants further investigation.
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