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Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Laura Keiko Fitzgibbon-Collins1, Nour Moussa2, Solve Elmstahl2

  • 1Western University, London, ON, Canada.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Increased cerebral blood flow may enhance balance in older adults at risk for dementia, particularly when vision is impaired. This suggests cerebral perfusion is crucial for maintaining motor control in those with cognitive decline.

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Area of Science:

  • Neurology
  • Gerontology
  • Cerebrovascular Health

Background:

  • Early Alzheimer's Disease (AD) presents subtle motor deficits like impaired balance and gait.
  • Reduced cerebral blood flow (CBF) correlates with dementia progression.

Purpose of the Study:

  • To investigate the association between enhanced CBF and improved balance in older adults.
  • To determine if this association differs between cognitively intact individuals and those at risk for dementia.

Main Methods:

  • 401 participants from the "Good Aging in Scania" cohort were assessed using the Mini-Mental State Examination (MMSE).
  • Participants were categorized into dementia risk (MMSE < 27) or cognitively intact (MMSE ≥ 27) groups.
  • Middle cerebral artery velocity (MCAv) and single-leg balance (eyes open/closed) were measured; regression analysis was performed.

Main Results:

  • Individuals at risk for dementia (MMSE < 27) showed a significant positive association between MCAv and single-leg balance time in eyes-closed conditions (p < 0.05).
  • No significant association was found in the eyes-open condition or among cognitively intact participants.

Conclusions:

  • In individuals with lower general cognition and dementia risk, better cerebral perfusion may offset cognitive and motor integration deficits.
  • Cerebral blood flow appears to be a limiting factor for balance control, especially when visual input is removed.