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Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
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Related Experiment Video

Updated: May 7, 2026

Performing and Processing FNA of Anterior Fat Pad for Amyloid
09:41

Performing and Processing FNA of Anterior Fat Pad for Amyloid

Published on: October 30, 2010

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Prognostication: A Young Patient With AA Amyloidosis.

Jennifer Inglis-Taylor1, Laurie Powell1

  • 1Palliative Care, Great Western Hospital, Swindon, GBR.

Cureus
|December 26, 2025
PubMed
Summary

This case study highlights challenges in providing advanced care for young patients with end-stage renal failure due to AA amyloidosis from IV heroin use. Multidisciplinary input and clear communication facilitated ethical and prognostic management.

Area of Science:

  • Nephrology
  • Palliative Care
  • Medical Ethics

Background:

  • Young patients with multiple comorbidities present prognostic uncertainty.
Keywords:
aa amyloidosisadvanced care planningend-of-life and hospice careopioid prescribingwritten and verbal communication

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  • End-stage renal failure (ESRF) secondary to AA amyloidosis from intravenous (IV) heroin use poses unique clinical challenges.
  • Managing complex cases requires addressing ethical dilemmas, pain management, and advanced care planning.