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High-Dose Biotin Supplementation Exacerbates Chronic Migraine: A Case Report

Aiman Abdullah Sanosi1

  • 1Department of Medicine, University of Jeddah, Jeddah, Saudi Arabia.

International Medical Case Reports Journal
|December 26, 2025
PubMed
Summary

High-dose biotin supplementation may worsen chronic migraine. A case study found that 10,000 mcg of biotin daily exacerbated a patient's long-standing migraine, leading to daily severe headaches. Discontinuation improved symptoms.

Keywords:
biotinheadachelife qualityneurological effectsworsening outcomes

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