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Related Concept Videos

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Related Experiment Video

Updated: May 7, 2026

Quantitation of Protein Expression and Co-localization Using Multiplexed Immuno-histochemical Staining and Multispectral Imaging
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Revealing Prostate Calcification Heterogeneity through Their Elemental Distribution.

Sarah B Gosling1, Emily L Arnold2, Lois Adams1

  • 1School of Chemical and Physical Sciences, Keele University, Staffordshire, Keele ST5 5BG, U.K.

Chemical & Biomedical Imaging
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Prostate calcifications reveal elemental differences linked to cancer. Specific metal ratios in these calcifications may serve as novel biomarkers for prostate cancer detection.

Keywords:
X-ray fluorescencebiomarkerscalcificationsmappingprostate cancersynchrotron

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Area of Science:

  • Biogeochemistry
  • Medical Physics
  • Urological Oncology

Background:

  • Prostate calcifications provide insights into the local ionic environment.
  • Investigating prostate calcification chemistry is crucial for identifying potential cancer biomarkers.

Purpose of the Study:

  • To investigate the elemental heterogeneity within human prostate calcifications.
  • To explore the relationship between calcification chemistry and prostate cancer grade.

Main Methods:

  • X-ray fluorescence (XRF) mapping was performed on 72 human prostate calcifications.
  • Elemental composition was analyzed at the I18 beamline at Diamond Light Source.
  • Spatial distribution of elements from the center to the edge of calcifications was examined.

Main Results:

  • Demonstrated heterogeneity in elemental composition within prostate calcifications.
  • Observed lower relative levels of minor elements at the center versus the edge.
  • Identified higher levels of zinc at the calcification center.
  • Found correlations between average ratios of Fe, Cr, Mn, Cu, and Ni and prostate cancer grade group.

Conclusions:

  • Prostate calcifications exhibit significant elemental heterogeneity.
  • Elemental profiles, particularly ratios of specific metals, are linked to prostate cancer grade.
  • These findings suggest prostate calcifications as a potential source for novel prostate cancer biomarkers.