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Multimodal Optical Imaging Platform for Studying Cellular Metabolism

Multimodal Optical Imaging Platform for Studying Cellular Metabolism

Published on: June 6, 2025

Stimulated Raman Scattering Imaging Enabled Biomarker Discovery for Precision Medicine.

Yuhui Li¹, Jianlin Liu¹, Shuhua Yue¹

¹Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Key Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology, National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering), School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China.

Chemical & Biomedical Imaging

|December 26, 2025

Summary

This summary is machine-generated.

Stimulated Raman scattering (SRS) microscopy offers label-free, high-resolution imaging for discovering metabolic biomarkers. This advances precision diagnosis and personalized treatment by overcoming limitations of traditional metabolomics.

Keywords:

biomarkers human diseases metabolism precision medicine stimulated Raman scattering microscopy

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Area of Science:

Biomedical Optics
Molecular Imaging
Precision Medicine

Background:

Metabolic dysregulation is key to disease development and progression.
Accurate disease diagnosis and personalized treatment rely on molecular biomarkers.
Current metabolomics methods are destructive and lack spatial resolution for dynamic intracellular processes.

Purpose of the Study:

To review advancements in Stimulated Raman Scattering (SRS) microscopy for biomarker discovery.
To highlight SRS applications in precision diagnosis and personalized medicine.
To discuss future trends in SRS imaging for metabolic research.

Main Methods:

Stimulated Raman scattering (SRS) microscopy enables label-free, sensitive, and specific molecular imaging.
SRS provides subcellular resolution, overcoming limitations of traditional metabolomics.
Integration of Raman-active probes allows real-time tracking of biomolecules and metabolic processes.

Main Results:

SRS microscopy facilitates the discovery of novel metabolic biomarkers.
This technology supports quantitative measurements of intracellular metabolic heterogeneity.
SRS imaging aids in identifying biomarkers for disease diagnosis and treatment.

Conclusions:

SRS microscopy is a powerful tool for label-free, high-resolution metabolic imaging.
It significantly enhances biomarker discovery for precision medicine.
Future developments in SRS technology promise further breakthroughs in understanding and treating diseases.