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Updated: Jan 7, 2026

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum
Published on: December 4, 2015
Blood group antigens and malaria susceptibility
Fang-Fang Liu1, Jing Liang2, Ming Gao3
1Department of Pathology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
None:
Blood-group antigens are increasingly recognized as key modulators of malaria susceptibility. This review synthesizes current evidence on how erythrocyte surface molecules shape parasite invasion, cytoadherence, immune evasion, and disease severity. We focus on a curated set of systems, ABO, Duffy, MNS, Gerbich, Knops, Diego, and others, and outline their molecular mechanisms affecting malaria. Population heterogeneity, parasite-host adaptations/counter-adaptations, and clinical implications for risk stratification, transfusion safety, and vaccine design are also discussed.
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