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Covalent Fragment Screening Using the Quantitative Irreversible Tethering Assay
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The Current Toolbox for Covalent Inhibitors: From Hit Identification to Drug Discovery

Mengke You1,2, Hong Liu1,2,3, Chunpu Li1,2,3

  • 1State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

JACS Au
|December 26, 2025
PubMed

Keywords:
covalent inhibitordrug designelectrophile screeningtechnology convergenceundruggable targets

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