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Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

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Published on: March 15, 2024

Exploring the Therapeutic Potential of Ferroptosis in Gastric Cancer.

Ruiyun Chen¹, Qian Ju¹, Liming Feng¹

¹Department of Gastrointestinal Surgery, Qingdao Central Hospital, University of Health and Rehabilitation Sciences (Qingdao Central Hospital), Qingdao, Shandong, People's Republic of China.

Cancer Management and Research

|December 26, 2025

Summary

Targeting ferroptosis, an iron-dependent cell death, offers new gastric cancer (GC) therapies. Inducing ferroptosis via natural compounds or nanoparticles can overcome chemoresistance and enhance immunotherapy for GC treatment.

Keywords:

chemotherapy resistance ferroptosis gastric cancer immunotherapy nanoparticle materials

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Area of Science:

Biochemistry
Oncology
Cell Biology

Background:

Ferroptosis, characterized by iron-dependent lipid peroxidation, is crucial in gastric cancer (GC) progression.
Dysregulation of ferroptosis contributes to GC occurrence, metastasis, and therapeutic resistance.

Purpose of the Study:

To review ferroptosis mechanisms in GC.
To explore therapeutic strategies targeting ferroptosis for GC treatment.

Main Methods:

Literature review of ferroptosis mechanisms and therapeutic targets in GC.
Analysis of natural products, nanoparticles, and drugs impacting ferroptosis in GC.

Main Results:

Targeting ferroptosis can modulate GC cell sensitivity to chemotherapy and immunotherapy.
Natural plant extracts and traditional medicines induce ferroptosis via p53 activation and NRF2 inhibition.
Nanoparticles show potential in delivering ferroptosis-inducing agents to suppress GC and GCSC growth.

Conclusions:

Ferroptosis induction presents a promising therapeutic strategy for GC.
Novel approaches including natural compounds, nanoparticles, and specific drugs offer new avenues for clinical intervention in GC treatment.