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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
Published on: September 20, 2018
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Clinical Manifestations
Layaly Shihadeh1, Stephen A Coombes2,3, Emily Ahne1
1Florida Atlantic University, Davie, FL, USA.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
Summary
Intrusion percentages in verbal fluency tasks are linked to cognitive decline and brain changes. Higher intrusions correlate with dementia and reduced frontal lobe volume, suggesting a potential marker for aging-related cognitive impairment.
Area of Science:
- Neuroscience
- Cognitive Psychology
- Gerontology
Background:
- Verbal memory intrusions are known indicators of cognitive decline in aging.
- The significance of intrusions in verbal fluency (VF) tasks is less understood.
Purpose of the Study:
- To investigate if intrusion percentages in phonemic (PF) and category (CF) VF tasks differ across cognitive diagnoses.
- To examine these differences longitudinally over three years.
- To determine the association between VF intrusions and frontal, temporal, and hippocampal brain volumes.
Main Methods:
- Analysis of participants from the 1Florida Alzheimer's Disease Research Center (ADRC) with varying cognitive statuses (cognitively normal, MCI, dementia).
- Intrusion percentages from PF and CF tasks were collected over three years.
- Brain volumes were assessed using MRI scans at baseline.
Main Results:
- Intrusion percentages significantly differed across diagnostic groups at years 2 and 3, indicating an association with cognitive status.
- Individuals with dementia showed higher intrusion percentages compared to cognitively normal individuals.
- Higher baseline VF intrusion percentages correlated with reduced volumes in frontal and temporal brain regions, particularly the left frontal pole and left caudal mid-frontal areas.
Conclusions:
- Intrusion percentages in verbal fluency tasks may serve as a sensitive indicator of cognitive decline in aging.
- These intrusion percentages are associated with structural changes in the left frontal lobe.
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