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Clinical Manifestations.

Kiirtaara Aravindhan1, Ashwati Vipin1, Yi Jin Leow2

  • 1Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

This study found that "behavioral frailty," the combination of prefrailty and mild behavioral impairment (MBI), is linked to reduced cortical thickness in specific brain regions. These findings highlight structural brain changes associated with this condition.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Cognitive Science

Background:

  • Frailty and mild behavioral impairment (MBI) are individually linked to cognitive decline and dementia.
  • The combined impact of prefrailty and MBI, termed "behavioral frailty," on brain structure is not well understood.

Purpose of the Study:

  • To investigate the association between prefrailty, MBI, and their co-occurrence ("behavioral frailty") with cortical thickness.
  • To explore the structural brain correlates of "behavioral frailty" in a Southeast Asian population.

Main Methods:

  • Recruited 795 community-dwelling participants for the Biomarker and Cognition Study Singapore.
  • Assessed participants using the Mild Behavioural Impairment Checklist, Fried Frailty Phenotype (FFP), and neuropsychological tests.
  • Acquired and processed T1-weighted 3T MRI scans to analyze cortical thickness and other brain metrics.

Main Results:

  • 5.9% of participants exhibited prefrailty with MBI.
  • Significant differences in white matter hyperintensity volume and neurofilament-light levels were observed between groups.
  • Prefrailty with MBI was associated with reduced cortical thickness in the right insula, right temporal lobe, left lateral orbitofrontal cortex, and left entorhinal cortex.

Conclusions:

  • "Behavioral frailty" is associated with distinct patterns of cortical thinning in brain regions crucial for cognitive and emotional processing.
  • These findings contribute to understanding the structural brain changes underlying combined prefrailty and MBI.