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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Katherine A Koenig1, Xuemei Huang1, Aaron Bonner-Jackson2

  • 1Cleveland Clinic, Cleveland, OH, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Logopenic primary progressive aphasia (LPA) shows thinner cortex in language regions compared to amnestic mild cognitive impairment (aMCI) in Alzheimer's disease. Neuropsychological deficits correlate more broadly with brain changes in LPA patients.

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Area of Science:

  • Neurology
  • Neuroimaging
  • Cognitive Neuroscience

Background:

  • Logopenic primary progressive aphasia (LPA) involves early language decline, often associated with Alzheimer's disease (AD).
  • LPA is typically linked to left posterior tempero-parietal atrophy.
  • This study investigates cortical thickness (CT) differences between LPA and amnestic MCI (aMCI) in AD.

Purpose of the Study:

  • To identify distinct and overlapping MRI cortical thickness (CT) changes in LPA compared to aMCI in AD.
  • To correlate these brain changes with neuropsychological (NP) measures.

Main Methods:

  • MRI cortical thickness was measured in 26 LPA and 13 aMCI patients using Freesurfer.
  • Regression analyses, controlling for age, sex, and education, identified group differences in CT.
  • Significant CT regions were correlated with NP measures within each group.

Main Results:

  • LPA patients exhibited thinner cortex than aMCI patients in several regions, predominantly in the left hemisphere, including temporal and fusiform areas.
  • In aMCI, left superior temporal gyrus thickness correlated with recall, learning, attention, and executive function.
  • In LPA, significant correlations between CT and NP measures were more widespread, involving the left fusiform, parahippocampal, and angular gyri.

Conclusions:

  • LPA shows significantly thinner cortex in language and AD-related regions compared to aMCI, primarily in the left hemisphere.
  • Neuropsychological deficits are more broadly distributed with brain changes in LPA than in aMCI.
  • Understanding these specific brain changes aids in characterizing neurodegeneration and disease progression in LPA and aMCI.