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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Huitong Ding1, Xavier Serrano1, Edward Searls1

  • 1Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Repetitive head impacts (RHI) are linked to slower response times in cognitively intact older adults. This study used digital cognitive tests to identify subtle cognitive changes associated with RHI exposure.

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Gerontology

Background:

  • Repetitive head impacts (RHI) are increasingly linked to neurodegenerative diseases.
  • Research on RHI's impact on digital cognitive measures in older adults is limited.
  • Cognitively intact older adults with RHI history require further investigation.

Purpose of the Study:

  • To compare cognitive performance using digital tools between older adults with and without RHI history.
  • To identify specific cognitive deficits associated with RHI in a cognitively intact older population.
  • To explore the utility of digital neuropsychological measures in detecting RHI-related cognitive alterations.

Main Methods:

  • Utilized longitudinal data from the Boston University Alzheimer's Disease Research Center (BU ADRC).
  • Classified RHI exposure based on NINDS Traumatic Encephalopathy Syndrome (TES) criteria.
  • Administered the Defense Automated Neurobehavioral Assessment (DANA) digital cognitive battery to assess performance.

Main Results:

  • Included 97 cognitively intact older adults (22 with RHI history).
  • Participants with RHI showed significantly longer response times in Code Substitution and Procedural Response Time tasks.
  • No significant differences were found in Simple Response Time or Match-to-Sample tasks.

Conclusions:

  • RHI exposure is associated with specific deficits in response speed in cognitively intact older adults.
  • Findings suggest subtle cognitive alterations linked to RHI, potentially affecting frontal-mediated pathways.
  • Digital cognitive assessments can reveal RHI-related cognitive changes in older populations.