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Clinical Manifestations.

Leonardo Baracat Caria1, Salma Rose Imanari Ribeiz1,2, Camila Nascimento Mantelli3

  • 1Faculdade de Medicina de Jundiaí, Jundiaí, Sao Paulo, Brazil.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

This study found no link between childhood trauma and cognitive decline in psychiatric patients. Further research with diverse age groups is needed to fully understand this relationship.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Gerontology

Background:

  • Childhood trauma is linked to mental health disorders and potential neurocognitive changes.
  • Evidence suggests a possible increased risk of dementia following early trauma, but results are mixed.
  • This study investigates the connection between childhood trauma and dementia-related cognitive decline.

Purpose of the Study:

  • To examine the association between childhood trauma and neurocognitive decline in individuals with psychiatric disorders.
  • To determine if childhood trauma is a predictor of cognitive impairment in a psychiatric sample.

Main Methods:

  • 95 participants from the Biobank for Aging Studies of the University of Sao Paulo were assessed.
  • Childhood trauma was measured using the Childhood Trauma Questionnaire (CTQ).
  • Cognitive status was evaluated using the Clinical Dementia Rating (CDR) scale, with multivariable linear regression used for analysis.

Main Results:

  • Older age and lower education were associated with cognitive decline (CDR > 0).
  • No significant difference in CTQ scores was found between individuals with and without cognitive decline.
  • Multivariable regression analysis revealed no statistically significant association between childhood trauma (CTQ score) and cognitive decline (CDR).

Conclusions:

  • The study's findings do not support a relationship between childhood trauma and cognitive decline in this psychiatric sample.
  • Further research with older adults, both with and without mental disorders, is recommended to clarify this association.