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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

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Biomarkers.

Rachael E Wilson1, Ramiro Eduardo Rea Reyes2, Aaron Fredricks3

  • 1Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Capillary dried plasma spots (DPS) show promise for Alzheimer's disease (AD) biomarker analysis, offering a scalable remote collection method. This study optimized DPS analysis, demonstrating good analyte recovery and correlation with plasma for key AD markers.

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Proteomics

Background:

  • Alzheimer's disease (AD) staging relies on complex biomarker interplay.
  • Single biomarkers are insufficient for characterizing AD complexities.
  • The NULISAseq CNS panel detects 100+ CNS dysfunction biomarkers.

Purpose of the Study:

  • Optimize capillary dried plasma spot (DPS) analysis for CNS protein profiling.
  • Evaluate analyte recovery and correlation of DPS with plasma using the NULISAseq CNS panel.
  • Assess the feasibility of remote blood collection for biomarker evaluation.

Main Methods:

  • Stepwise optimization of buffer composition, volume, and incubation time for DPS.
  • Analysis of paired venous plasma and DPS samples from Alzheimer's Prevention participants (N=40).
  • Comparison of analyte recovery, detectability, and correlations between DPS and plasma.

Main Results:

  • Optimal DPS detectability (80%) achieved with 80uL diluent.
  • Decreasing buffer volume increased detectability (R²=1.00) down to 80uL.
  • High percent recovery (77-92%) for pTau species in DPS; 62/127 analytes significantly correlated with plasma.

Conclusions:

  • Capillary DPS samples are optimized and evaluated for targeted proteomic analysis.
  • Analyte recovery and correlations in DPS versus plasma vary by analyte.
  • Ongoing work includes further optimization for AD markers and evaluation of remote sampling devices.