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Updated: Jan 7, 2026

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
Published on: October 28, 2021
The Impact and Evaluation of Immune Checkpoint Inhibitors on Clinical Survival in Patients with Advanced
Yanbing Li1, Zijun Li1, Lingyu Cai1
1Department II of Oncology, The First People's Hospital of Jiujiang, Jiujiang City, China.
Abstract:
Osteosarcoma is an aggressive bone cancer primarily affecting children and adolescents, with low survival rates in advanced stages. A systematic review and meta-analysis were conducted following PRISMA guidelines to evaluate the impact of ICIs on survival and toxicity in advanced osteosarcoma. ICIs show potential in treating advanced osteosarcoma but are associated with significant toxicity and uncertain survival benefits. Further research is needed to define their role and identify biomarkers for predicting response. Close monitoring for adverse events is essential.
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