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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Si Won Ryoo1,2, William Z Lin2, Myuri Ruthirakuhan1,2

  • 1University of Toronto, Toronto, ON, Canada.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Linoleic acid (LA)-derived soluble epoxide hydrolase (sEH) diols are linked to increased cerebral small vessel disease and white matter damage in type 2 diabetes mellitus (T2DM). Targeting sEH may offer a therapeutic strategy for mitigating diabetes-related neurovascular damage.

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Area of Science:

  • Neuroscience
  • Metabolic Disorders
  • Biochemistry

Background:

  • Polyunsaturated fatty acids are metabolized into anti-inflammatory epoxides, but soluble epoxide hydrolase (sEH) converts them to cytotoxic diols.
  • Increased linoleic acid (LA)-derived diols correlate with cognitive decline in type 2 diabetes mellitus (T2DM) and white matter hyperintensities (WMH) in stroke patients.
  • The relationship between LA-derived diols and neuroimaging markers in T2DM remains unexplored.

Purpose of the Study:

  • To investigate the association between LA-derived diols and markers of cerebral small vessel disease (SVD) and white matter integrity in T2DM patients.
  • To explore the potential role of sEH in diabetes-related neurovascular damage.

Main Methods:

  • Quantified two unesterified LA-derived diols (9,10-DiHOME and 12,13-DiHOME) in serum from T2DM participants using ultra-high-performance liquid chromatography-mass spectrometry.
  • Assessed cerebral small vessel disease markers (perivascular spaces, WMH, lacunar infarcts) and white matter integrity (fractional anisotropy, mean diffusivity) via structural and diffusion tensor MRI.
  • Employed multiple linear regression analyses, controlling for relevant demographic, clinical, and genetic factors, with Bonferroni correction for multiple comparisons.

Main Results:

  • 9,10-DiHOME was associated with higher WMH and lacunar infarct volumes, and increased mean diffusivity (MD).
  • 12,13-DiHOME was associated with increased WMH volume.
  • Exploratory analyses revealed associations between both diols and WMH, lacunar infarcts, and MD in the parietal lobe, with 9,10-DiHOME also linked to lower fractional anisotropy (FA).

Conclusions:

  • LA-derived sEH diols are significantly associated with increased cerebral small vessel disease pathology and white matter microstructural damage in individuals with diabetes.
  • sEH inhibition presents a promising therapeutic avenue for preventing or treating neurovascular and white matter damage in the context of diabetes.