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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
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Clinical Manifestations.

Yaimara Gonzalez Pinero1,2, Wassim Tarraf3, Idaly Velez-Uribe4,5,6

  • 11 Florida Alzheimer's Disease Research Center (ADRC), Miami Beach, FL, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Subjective cognitive decline (SCD) severity, reported by individuals or informants, correlates with objective cognitive function in Hispanic older adults. Informant reports showed broader associations across cognitive domains than self-reports.

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Area of Science:

  • Neurology
  • Gerontology
  • Cognitive Science

Background:

  • Subjective cognitive decline (SCD) may precede objective cognitive impairment and Alzheimer's disease.
  • Limited data exists on SCD's clinical validity in underrepresented populations.
  • This study examines SCD in diverse Hispanic older adults.

Purpose of the Study:

  • To investigate the association between self- or informant-reported SCD severity and objective cognitive performance.
  • To assess the clinical utility of SCD measures in a diverse Hispanic population.

Main Methods:

  • 162 Hispanic adults without dementia and 135 informants were recruited.
  • Self (SCDQ) and informant (TheirSCDQ) versions of the SCD Questionnaire were used.
  • Linear regression analyzed SCD severity against objective cognitive tests (UDS3), adjusting for covariates.

Main Results:

  • SCDQ predicted executive function; TheirSCDQ predicted global cognition, memory, and executive function.
  • Associations were primarily observed in cognitively normal individuals.
  • Informant reports were associated with more cognitive domains than self-reports.

Conclusions:

  • SCD severity, particularly informant-reported, is linked to objective cognitive performance in Hispanic older adults.
  • Findings suggest potential clinical utility of SCD measures in this population.
  • Further research is needed to confirm SCD's predictive value for cognitive changes.