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Clinical Manifestations.

Elisa de Paula1, França Resende1, Leonardo Cruz de Souza2

  • 1Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

In Brazilian adults, elevated total tau levels correlated with poorer verbal memory, suggesting neurodegeneration impacts cognition. Beta-amyloid 42 and phosphorylated tau showed no significant verbal memory correlations.

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Area of Science:

  • Neuroscience
  • Biomarkers
  • Cognitive Science

Background:

  • Understanding Alzheimer's disease (AD) biomarkers and cognitive performance is crucial for diverse populations.
  • Studying underrepresented groups enhances the global applicability of AD diagnosis and therapies.

Purpose of the Study:

  • To investigate the relationship between AD cerebrospinal fluid (CSF) biomarkers and cognitive performance in a Brazilian population.
  • To explore how educational background influences these associations.

Main Methods:

  • Analyzed CSF biomarkers (p-tau, total tau, AB-42) and neuropsychological evaluations in 72 participants.
  • Participants included those diagnosed with AD, behavioral variant frontotemporal dementia (bvFTD), mild cognitive impairment (MCI), and unspecified dementia.
  • Assessed correlations using Spearman's rho.

Main Results:

  • Total tau showed a significant negative correlation with verbal memory (p=0.025).
  • Beta-amyloid 42 (AB-42) showed a significant positive correlation with verbal memory (p=0.024).
  • No significant correlations were found between phosphorylated tau and cognitive measures, nor between AB-42 and global cognitive function.

Conclusions:

  • In a Brazilian cohort with varied education, total tau levels significantly correlated with verbal memory performance.
  • Findings suggest cognitive impairment is linked to neurodegeneration rather than solely amyloidosis.
  • Further research is needed to understand the role of different biomarkers across diverse populations.