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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Kalyani Chaubey1,2,3,4, Lijun Dou3,5, Edwin Vázquez-Rosa1,2,3,4

  • 1Institute of Transformative Molecular Medicine, Case western Reserve University, Cleveland, OH, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Early Alzheimer's disease (AD) signatures in rats mirror human AD, with a neuroprotective compound normalizing these changes. This offers insight into preventing AD by targeting molecular mechanisms before cognitive decline.

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Area of Science:

  • Neuroscience
  • Proteomics
  • Metabolomics

Background:

  • Alzheimer's disease (AD) is a progressive brain disorder impacting behavior and cognition, often preceded by depression.
  • This study investigates early-stage AD molecular signatures in the TgF344AD rat model, focusing on the period of depression without cognitive impairment.

Purpose of the Study:

  • To identify early-stage proteomic and metabolomic signatures of Alzheimer's disease (AD) in the TgF344AD rat model.
  • To compare these signatures with human AD databases for clinical relevance.
  • To evaluate the efficacy of the neuroprotective compound P7C3-S243 in normalizing AD-associated molecular changes.

Main Methods:

  • TgF344AD rats exhibiting depression-like behavior but no cognitive impairment were treated with P7C3-S243 or vehicle for six months.
  • Brain proteomics and metabolomics were analyzed using UPLC-MS/MS and Metabolon, respectively.
  • Identified signatures were compared to human AD proteomic and metabolomic databases.

Main Results:

  • 904 proteins and 95 metabolites showed significant alterations in TgF344AD rats compared to wild-type littermates.
  • Many identified changes mirrored those found in human AD brain databases.
  • Treatment with P7C3-S243 normalized many common rat and human AD-associated molecular signatures.

Conclusions:

  • Common and unique molecular signatures of AD exist at proteomic and metabolomic levels between the TgF344 AD rat model and human AD brain.
  • The neuroprotective compound P7C3-S243 normalized shared AD-associated molecular patterns in rats, preventing disease onset.
  • Findings provide new insights into mechanisms for effective Alzheimer's disease prevention.