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Clinical Manifestations.

Nahuel Magrath Guimet1,2, Florentina Morello Garcia2,3,4, Loana De Los Santos2

  • 1Global Brain Health Institute, University of California, San Francisco, San Francisco, CA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
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PubMed
Summary
This summary is machine-generated.

Diagnosing frontotemporal lobar degeneration (FTLD) in Latin America varies significantly by subtype, with behavioral variant FTD (bvFTD) taking the longest and FTD-MND the shortest. Younger age and lower education correlate with delayed diagnoses, highlighting disparities.

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Area of Science:

  • Neuroscience
  • Neurology
  • Clinical Research

Background:

  • Frontotemporal lobar degeneration (FTLD) encompasses diverse syndromes like bvFTD, PPA variants, PSP, CBD, and FTD-MND.
  • Prolonged diagnostic timelines in FTLD negatively impact patient care and family outcomes.
  • Limited data exists on FTLD diagnostic timelines in Latin America, necessitating research to identify barriers.

Purpose of the Study:

  • To analyze diagnostic timelines for various FTLD phenotypes in Latin America.
  • To identify clinical and sociodemographic factors influencing diagnostic delays.
  • To inform strategies for improving timely diagnosis and treatment.

Main Methods:

  • Analysis of 415 cases from the RedLat consortium (2021-2024).
  • Categorization of FTLD subtypes including bvFTD, svPPA, nfvPPA, PSP, CBS, and FTD-MND.
  • Calculation of time from first reported symptom (TDFRS) and FTLD-criteria symptom (TDFCS) to diagnosis.

Main Results:

  • Significant variability in diagnostic timelines across FTLD phenotypes.
  • Behavioral variant FTD (bvFTD) showed the longest TDFRS (3.54 years) and TDFCS (3.09 years).
  • Frontotemporal dementia with motor neuron disease (FTD-MND) had the shortest timelines (1.29 years). Younger age and lower education levels were linked to longer diagnostic delays.

Conclusions:

  • Substantial diagnostic timeline disparities exist across FTLD subtypes in Latin America.
  • bvFTD diagnosis is prolonged, while FTD-MND is relatively swift.
  • Sociodemographic factors like age and education influence diagnostic timeliness, underscoring the need for targeted interventions to improve care access and outcomes.