Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Isolating fast and slow flows in three-dimensional fluid dynamics.

Scientific reports·2026
Same author

Prediction of Alzheimer's disease risk factors from retinal images via deep learning: Development and validation of biologically relevant morphological associations in the UK Biobank.

Journal of Alzheimer's disease : JAD·2026
Same author

Towards tDCS Digital Twins using Deep Learning-based Direct Estimation of Personalized Electrical Field Maps from T1-Weighted MRI.

Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention·2026
Same author

Dopaminergic expression and the regulation of foraging in response to water stress.

Journal of insect physiology·2026
Same author

Improved performance and design of a low-cost laparoscope to enable laparoscopic surgery in low-income countries.

Biophotonics discovery·2026
Same author

A pro-carcinogenic bacterial toxin binds claudin-4 to cleave E-cadherin.

Nature·2026
Same journal

Evaluation of CSF and plasma tau species as fluid surrogate candidates for tau PET in prodromal to moderate Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Associations of self-reported obstructive sleep apnea with cognition and dementia risk in cognitively unimpaired middle-aged adults.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Inflammation profiles in Alzheimer's disease relate to cognition and neurodegeneration.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Cardiovascular-kidney-metabolic syndrome stage modifies the efficacy of intensive blood pressure control on cognitive outcomes: A post hoc analysis of SPRINT MIND.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Evidence of APOE4-related brain vulnerabilities in verbal memory systems in midlife women.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Changes in DNA methylation-based aging predicts brain damage and dementia and reflects life-course cardiovascular risk.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
See all related articles

Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

Biomarkers.

Tyler Ann Busch1, Kevin Iversen1, Skylar Stolte1

  • 1University of Florida, Gainesville, FL, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Accurate head anatomy modeling in older adults is crucial for effective transcranial direct current stimulation (tDCS). Individual anatomical differences, particularly fat and cortical bone, significantly alter current flow in the aging brain.

More Related Videos

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

Related Experiment Videos

Last Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Gerontology

Background:

  • Transcranial direct current stimulation (tDCS) shows promise for mitigating age-related cognitive decline.
  • Individual tDCS responses are influenced by anatomical variations, as indicated by finite element method (FEM) modeling.
  • Current head segmentation tools are not optimized for older adult anatomy, leading to inaccurate tDCS current distribution predictions.

Purpose of the Study:

  • To create the largest dataset of manually segmented T1-weighted images from cognitively healthy older adults.
  • To investigate the impact of corrected older adult anatomy on tDCS current distribution.
  • To identify key anatomical predictors of tDCS current density in the aging brain.

Main Methods:

  • Segmentation of heads into 11 tissue types.
  • Modification of the ROAST tool to accommodate 11 tissues for tDCS modeling (2mA, F4 anode, F3 cathode).
  • Calculation of median current densities (J) in the Superior Frontal Gyrus (SFG), Inferior Frontal Gyrus (IFG), and Middle Frontal Gyrus (MFG) using multiple linear regression.

Main Results:

  • Regression models explained significant variance in current density (43.2-49.4%) across ROIs.
  • Fat and cortical bone volumes were significant negative predictors of current density.
  • Higher brain-to-intracranial volume positively correlated with current density.

Conclusions:

  • Anatomical variability, especially fat and cortical bone, significantly influences tDCS current distribution in older adults.
  • Fat's insulating properties and cortical bone's resistive properties reduce current density.
  • Brain atrophy, indicated by lower brain-to-intracranial volume, leads to current shunting within CSF, reducing current density in the brain.