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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Anna Brugulat-Serrat1,2,3,4,5, Elena Tsoy6,7, Gonzalo Sánchez-Benavides3,8,9

  • 1Faculty of Medicine, University of Vic-Central University of Catalonia (UVic-UCC), Vic/Manresa, Catalonia, Spain.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

The tablet-based TabCAT Favorites test shows promise for detecting early Alzheimer's disease (AD) pathology in cognitively unimpaired individuals. This sensitive episodic memory test can identify subtle cognitive changes linked to AD biomarkers and predict future clinical progression.

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Area of Science:

  • Neurology
  • Neuroscience
  • Biomarkers

Background:

  • Sensitive memory tests are crucial for early detection of Alzheimer's disease (AD) pathology in cognitively unimpaired (CU) individuals.
  • The EPAD Longitudinal Cohort Study (LCS) provided a large multinational sample for this investigation.
  • Investigating early AD changes requires methods sensitive to subtle memory impairments.

Purpose of the Study:

  • To assess the association between a computerized episodic memory test (TabCAT Favorites) and AD cerebrospinal fluid (CSF) biomarker status in CU individuals.
  • To evaluate the predictive value of the TabCAT Favorites test for future clinical progression in the AD continuum.
  • To compare the utility of TabCAT Favorites with the RBANS Memory Index (RBANS-MI) in detecting early AD-related cognitive changes.

Main Methods:

  • 727 CU individuals from the EPAD LCS with available TabCAT Favorites performance and CSF biomarkers were analyzed.
  • Multinomial logistic regression examined associations between memory performance and AD biomarker (ATN) stages.
  • Cox proportional hazard models assessed the prediction of Clinical Dementia Rating (CDR) score changes using an optimal Favorites cutoff.

Main Results:

  • Poorer TabCAT Favorites performance was associated with a higher likelihood of A+T+ biomarker status (OR=0.92, p=.030).
  • No significant association was found between RBANS-MI and ATN status.
  • TabCAT Favorites demonstrated discriminative validity in predicting progression to CDR>0 among A+T+ individuals (p=.014).

Conclusions:

  • The tablet-based TabCAT Favorites test is a sensitive tool for detecting cognitive changes in the early AD continuum.
  • TabCAT Favorites offers a valuable alternative to traditional episodic memory tests for clinical and research applications.
  • This computerized test aids in identifying individuals with early AD pathology and predicting cognitive decline.