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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Biomarkers.

Marufjon Salokhiddinov1, Dileep Kumar2, Dharmesh Singh2

  • 1Tashkent Medical Academy, Tashkent, Tashkent, Uzbekistan.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Automated MRI analysis reveals significant volume loss in the left medial temporal lobe (MTL) and lateral temporal lobe (LTL) in early Alzheimer's disease (AD). These findings highlight the potential of advanced imaging techniques for early AD diagnosis and monitoring disease progression.

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Area of Science:

  • Neuroimaging
  • Radiology
  • Medical Diagnostics

Background:

  • Alzheimer's disease (AD) diagnosis relies on identifying neurodegenerative changes.
  • Early detection of AD is crucial for timely intervention and management.
  • Temporal lobe atrophy is a key indicator in AD progression.

Purpose of the Study:

  • To evaluate automated volumetric measurement techniques for early AD diagnosis.
  • To assess the significance of medial temporal lobe (MTL) and lateral temporal lobe (LTL) volume changes in mild AD.
  • To investigate the utility of automated MRI analysis for AD detection.

Main Methods:

  • Utilized 3T MPRAGE MRI scans from 39 healthy controls (HC) and 39 mild AD patients (ADNI Phase 3).
  • Employed a Cascaded Weakly Supervised Confidence Integration Network (CINet) for automated volumetric quantification.
  • Focused on analyzing atrophies in MTL and LTL regions, including sub-divisions.

Main Results:

  • Significant reduction (p < 0.05) in left LTL volume (∼13%) in AD patients compared to HC.
  • Significant reduction (p < 0.05) in right LTL volume (∼10.50%) in AD patients compared to HC.
  • Volume loss in LTL was consistent across both genders in AD patients.

Conclusions:

  • Observed greater volume loss in left MTL and LTL regions, indicating asymmetric atrophy in mild AD.
  • Automated volumetric measurement techniques are significant for AD diagnosis and monitoring.
  • The study provides valuable insights for early AD intervention strategies.