Related Experiment Video
Updated: Jan 7, 2026

Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane
Published on: December 9, 2022
High intensity focused ultrasound in small saphenous vein incompetence: a pilot feasibility study
Paolo Casoni1, Emanuele Nanni1, Matteo Pizzamiglio1
1Vascular Surgery Service, Ippocrate Vein Clinic, Parma, Italy.
Abstract:
BackgroundThis study explores the effectiveness of High Intensity Focused Ultrasound (HIFU) in treating incompetence of the small saphenous vein (SSV).Materials and methodsPatients diagnosed with SSV incompetence received HIFU treatment. The primary outcome measured was the rate of SSV competent shrinkage or closure after 1 year.ResultsAmong the 292 legs treated with HIFU for chronic venous disease, 15 (5.1%) were for SSV incompetence. Quality of life, assessed using the CIVIQ-20, showed a significant improvement at 3 months post-treatment, decreasing from 38.9 ± 9.1 to 24.3 ± 2.0 (p < .01). The rVCSS also improved, declining from 6.5 ± 1.7 to 5.0 ± 1.0, although this change was not statistically significant (p = ns). All SSVs were closed or competent with evidence of shrinkage at 1 week, 3 months, 6 months, and 1 year following HIFU. No recurrent varicose veins were identified during the follow-up period.ConclusionThese initial findings indicate that HIFU may be an effective option for addressing SSV incompetence. Additional studies are necessary to compare this method with other treatments and to evaluate long-term results with a more robust patient cohort.
Related Concept Videos
Varicose Veins II: Diagnostic Studies and Interprofessional Care
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

