Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>GCH1</i> p.Ser80Asn Confers Risk for Parkinson's Disease in East Asian Populations.

medRxiv : the preprint server for health sciences·2026
Same author

Neuropathologic Correlates of Seizures in Patients With Alzheimer Disease and Dementia With Lewy Bodies.

Neurology·2026
Same author

Commensal Cutibacterium acnes-derived indolelactic acid safeguards skin barrier function through the aryl hydrocarbon receptor.

Cell reports. Medicine·2026
Same author

Ferroelectric-Polarization-Modulated 2D Floating-Gate Memory Enabling a 10<sup>6</sup> On/Off Ratio under ±1 V Gate-Voltage Sweep.

Nano letters·2026
Same author

Participant-level anomaly detection for generation and load data using dual-side LSTMs.

Scientific reports·2026
Same author

E3 ubiquitin ligases in neurodegenerative diseases.

Military Medical Research·2026
Same journal

Unveiling the procoagulant state in Alzheimer's disease: A novel PET imaging strategy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Estimated labor market outcomes of people progressing from preclinical to early-stage Alzheimer's disease in the United States.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Amyloid exacerbates tau and alpha-synuclein pathologies, behavioral impairments, and neuroinflammation in a mixed dementia model.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Multimorbidity burden and patterns associated with DeepBrainNet-derived brain-age gap in dementia-free older adults: A community-based study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Reply to "Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities".

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
See all related articles

Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

Biomarkers.

Somayeh Ebrahimkhani1, Guimeng Liu1, Tianze Yu1

  • 1Singapore University of Technology and Design (SUTD), Singapore, Singapore.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

This study introduces Brain-FM, a novel AI system for neurodegenerative disease diagnosis. Brain-FM enhances brain health diagnostics by integrating visual and text data, improving accuracy in interpreting medical images.

More Related Videos

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

Related Experiment Videos

Last Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

Area of Science:

  • Artificial Intelligence
  • Medical Imaging
  • Neuroscience

Background:

  • Current AI models for neurodegenerative diseases (NDs) are limited by task-specificity and lack diagnostic reasoning capabilities.
  • Advancements in multimodal foundation models (FMs) offer potential for more sophisticated healthcare AI.
  • Brain-FM is a novel FM-powered visual question answering (VQA) system designed to overcome these limitations.

Purpose of the Study:

  • To develop and evaluate Brain-FM, a multimodal foundation model for enhanced brain health diagnostics.
  • To improve the interpretation of complex clinical and imaging data in neurodegenerative disease diagnosis.
  • To create an adaptable AI system for diverse healthcare tasks and patient subpopulations.

Main Methods:

  • Constructed the PMC-Dementia dataset from 4.5 million scientific publications, focusing on ND subtypes with image-caption pairs.
  • Employed and integrated two visual encoders, CLIP and DINOv2, to build the Brain-FM model.
  • Generated a VQA dataset using MRI images from 200 participants in the AIBL study to evaluate visual reasoning.

Main Results:

  • Different visual encoders exhibited varied performance in visual reasoning tasks on the AIBL dataset.
  • Integrating DINOv2 with CLIP significantly enhanced Brain-FM's visual interpretation and instruction-following accuracy and precision.
  • Brain-FM demonstrated accurate visual question answering, outperforming CLIP alone when using the DINOv2-CLIP integration.

Conclusions:

  • Brain-FM, a multimodal FM, is tailored for brain health applications, enhancing diagnostic reasoning through visual-text data integration.
  • Mixing visual features and fine-tuning on the PMC-Dementia dataset achieved high accuracy.
  • Brain-FM represents a significant advancement towards more flexible and generalizable AI systems for brain health diagnostics.