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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Jianqiao Tian1,2, Wen Zhang3, Sheelakumari Raghavan1

  • 1Mayo Clinic, Rochester, MN, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

White matter integrity influences tau accumulation rates, with tau progression further damaging white matter. These associations, particularly the impact of vascular risk and tau accumulation on white matter, show notable sex differences.

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Area of Science:

  • Neuroimaging
  • Neurodegenerative Diseases
  • White Matter Integrity

Background:

  • White matter (WM) facilitates tau pathology spread but is also compromised by tau accumulation.
  • Understanding the dynamic relationship between tau and WM is crucial for neurodegenerative disease research.

Purpose of the Study:

  • To investigate the longitudinal associations between tau accumulation and white matter (WM) integrity.
  • To explore potential sex differences in these relationships.

Main Methods:

  • Utilized longitudinal diffusion MRI and flortaucipir PET data from 374 participants.
  • Assessed WM integrity using neurite density index (NDI) in the inferior temporal-white matter (IT-WM) tract.
  • Employed structural equation modeling (SEM) to analyze relationships between tau metrics and WM integrity.

Main Results:

  • Baseline tau levels influenced the rate of subsequent tau accumulation, mediated by IT-WM integrity.
  • Progressive tau accumulation was associated with a decline in IT-WM neurite density index (NDI).
  • These relationships were more pronounced in males, who also showed greater vascular risk impact on WM health and higher rates of tau accumulation in females.

Conclusions:

  • Intact white matter plays a mechanistic role in modulating tau accumulation.
  • Deterioration of white matter is linked to increased rates of tau accumulation.
  • Significant sex differences in the tau-WM relationship warrant further investigation.