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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Anupa Manjitha Ekanayake Mudiyanselage1, Qing Yang1, Senal Peiris1

  • 1Pennsylvania State University College of Medicine, Hershey, PA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Functional magnetic resonance imaging (fMRI) reveals temporoparietal junction (TPJ) activity is linked to odor identification in mild cognitive impairment (MCI). Reduced TPJ connectivity correlates with amyloid pathology, potentially causing olfactory dysfunction in MCI patients.

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Medical Imaging

Background:

  • Investigating the temporoparietial junction's (TPJ) role in odor identification using functional magnetic resonance imaging (fMRI).
  • Comparing fMRI activity in the TPJ between healthy controls (HC) and individuals with mild cognitive impairment (MCI).
  • Hypothesizing a negative correlation between TPJ fMRI activity and amyloid-beta (Aβ) standardized uptake value ratio (SUVr).

Purpose of the Study:

  • To explore the TPJ's function in odor identification via fMRI in HC and MCI subjects.
  • To determine the relationship between TPJ activity, cognitive status, and brain amyloid deposition.
  • To examine how age and group interact with TPJ activity and Aβ burden.

Main Methods:

  • Utilizing fMRI with an olfactory oddball detection task in HC and MCI participants.
  • Administering neuropsychological tests and Aβ-PET imaging to quantify beta-amyloid burden.
  • Analyzing TPJ activity during odor identification and its correlation with Aβ SUVr values.

Main Results:

  • Significant differences in TPJ activity were observed between HC and MCI groups during the olfactory task.
  • Negative correlations were found between TPJ activity and Aβ SUVr in olfactory regions.
  • An interaction term (TPJ fMRI activity x age x group) positively correlated with SUVr in specific brain areas like the hippocampus.

Conclusions:

  • TPJ connectivity with olfactory regions diminishes with increased amyloid pathology, potentially leading to olfactory dysfunction.
  • fMRI activity in the TPJ during olfactory tasks correlates with brain amyloid deposition, indicating a brain-behavior link in MCI.
  • Further research with larger sample sizes is needed to strengthen the observed correlations.