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Clinical Manifestations.

Julia A Sinople1, Em Teixeira1, Charles Denby1

  • 1Rhode Island Hospital, Providence, RI, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

New digital cognitive tests show promise in detecting early Alzheimer's disease (AD) risk. These tools, including the Rhode Island Mobile Cognitive Assessment Tool (RIMCAT), are sensitive to amyloid levels in cognitively unimpaired older adults.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Biomarker Research

Background:

  • Digital cognitive screening offers potential for early Alzheimer's disease and related dementias (ADRD) detection.
  • Current digital tools lack sensitivity for preclinical ADRD stages.
  • The Rhode Island Mobile Cognitive Assessment Tool (RIMCAT) shows high accuracy in distinguishing impaired and unimpaired individuals.

Purpose of the Study:

  • Enhance RIMCAT's sensitivity for early/preclinical AD risk detection.
  • Investigate four new cognitive paradigms targeting brain regions affected early in AD.
  • Assess the relationship between digital cognitive assessments and plasma amyloid-beta 42/40 (Ab42/40) levels in cognitively unimpaired older adults.

Main Methods:

  • Recruited 24 cognitively unimpaired older adults (mean age 73).
  • Analyzed plasma samples for amyloid probability score (APS) using the PrecivityAD platform.
  • Administered RIMCAT and four novel computerized subtests (perceptual discrimination, familiarity memory, feature binding, response inhibition).

Main Results:

  • Individuals with elevated amyloid burden performed worse on RIMCAT and three new subtests (p < .05).
  • A higher Ab42/40 ratio (less amyloid) correlated with better performance on RIMCAT and all new subtests (r = .23-.40).

Conclusions:

  • Novel digital cognitive screening measures demonstrate preliminary sensitivity to amyloid burden in cognitively unimpaired individuals.
  • These findings suggest potential for digital tools in early AD detection.
  • Further validation with larger samples and additional biomarkers (e.g., tau) is warranted.