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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
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Clinical Manifestations.

Annie Ching1, Anson Wong2, Bora Nam1

  • 1University of California San Francisco School of Nursing, San Francisco, CA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

The ARISE pilot study shows community partnerships are key for recruiting diverse Asian American elders for Alzheimer's disease and related dementias (ADRD) research. Culturally sensitive methods improve participation and data collection in underrepresented groups.

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Area of Science:

  • Neuroscience
  • Public Health
  • Sociology

Background:

  • Discrimination is linked to Alzheimer's disease and related dementias (ADRD) risk.
  • This association is understudied in Asian Americans, particularly amid rising anti-Asian sentiment.
  • The ARISE pilot study addresses this gap by examining discrimination's impact on ADRD risk in specific Asian American communities.

Purpose of the Study:

  • To explore the associations between experiences of discrimination and ADRD risk in Chinese-, Korean-, and Vietnamese-speaking older adults.
  • To evaluate the feasibility of recruiting these populations for cognitive testing and biological sample collection.
  • To highlight cultural and linguistic considerations essential for ADRD research involving diverse ethnic groups.

Main Methods:

  • Participants undergo assessments in their primary language, including blood draws for biomarkers and interviews covering cognitive function, health, and discrimination experiences.
  • Validated instruments were sourced or translated/adapted per WHO guidelines, with examiners trained for cultural appropriateness.
  • Recruitment strategies were co-developed with community organizations, adapting procedures and offering culturally relevant incentives to build trust and encourage participation.

Main Results:

  • The ARISE pilot study successfully enrolled 252 participants (112 Vietnamese, 56 Korean, 84 Chinese) as of January 23, 2025.
  • 217 participants completed both blood draws and interviews, demonstrating feasibility of the study procedures.
  • Tailored recruitment, community collaboration, and culturally sensitive approaches fostered trust, community, and retention.

Conclusions:

  • Collaborations with community partners were vital for the successful recruitment and completion of the ARISE pilot study.
  • The study demonstrates the feasibility of conducting cognitive assessments and collecting biological samples from older Asian Americans in ADRD research.
  • Future findings will inform ADRD research strategies for underrepresented populations, emphasizing cultural and linguistic adaptations.