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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

746
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

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Biomarkers.

Ming Ann Sim1,2, Hyung Won Choi1, Yuan Cai3

  • 1National University of Singapore, Singapore, Singapore, Singapore.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Researchers identified plasma protein signatures for cerebrovascular disease (CeVD) and its progression. These biomarkers, linked to inflammation and cell adhesion, may offer new avenues for CeVD detection and treatment.

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Area of Science:

  • Neuroscience
  • Biomarker Discovery
  • Proteomics

Background:

  • Cerebrovascular disease (CeVD) is linked to cognitive decline, but lacks validated blood biomarkers.
  • Early detection and intervention for CeVD are limited by the absence of reliable biomarkers.

Purpose of the Study:

  • To identify plasma protein signatures associated with CeVD.
  • To explore protein associations with CeVD phenotypes and longitudinal progression.

Main Methods:

  • Prospective cohort study with 4-year follow-up and serial brain MRI.
  • Plasma protein profiling using Olink Explore (1536 proteins).
  • Multivariable regression analysis to associate proteins with CeVD imaging markers.

Main Results:

  • 345 proteins associated with CeVD, enriched in inflammation, immune dysregulation, and cell adhesion pathways.
  • Distinct protein signatures identified for lacunes, cerebral microbleeds (CMBs), cortical infarcts, and white matter hyperintensity volume (WMHv).
  • NFL, CHRDL1, and NTproBNP identified as significant proteins for specific CeVD markers; NFL also linked to WMHv progression.

Conclusions:

  • Plasma proteomic signatures for CeVD have been identified.
  • These findings highlight potential therapeutic targets for CeVD pathology.
  • Further research is needed to elucidate the mechanistic roles of these plasma biomarkers.