Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

746
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
746
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

511
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
511

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Music as a scientific metaphor for mind and brain.

Neuroscience and biobehavioral reviews·2026
Same author

Correction: The role of brain health and resilience in reshaping trajectories of late-life neuropsychiatric disorders.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same author

Evaluation of perception towards brain health in Nigeria: Results from a nationwide awareness survey.

Journal of public health in Africa·2026
Same author

Sociodemographic variables as predictors of antidepressant treatment outcome in major depressive disorder.

Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)·2026
Same author

Association of apolipoprotein E variants on Alzheimer's disease in Latin America: A systematic review and meta-analysis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Plasma ATN biomarkers across the alzheimer's disease continuum in a Chilean community- and clinic-based cohort.

Alzheimer's research & therapy·2026
Same journal

Unveiling the procoagulant state in Alzheimer's disease: A novel PET imaging strategy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Estimated labor market outcomes of people progressing from preclinical to early-stage Alzheimer's disease in the United States.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Amyloid exacerbates tau and alpha-synuclein pathologies, behavioral impairments, and neuroinflammation in a mixed dementia model.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Multimorbidity burden and patterns associated with DeepBrainNet-derived brain-age gap in dementia-free older adults: A community-based study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Reply to "Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities".

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
See all related articles

Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

Biomarkers.

Nickole P Marin-Díaz1,2, Matias Pizarro3,4, Hernan Hernandez1

  • 1Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago, Chile.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

An Allostatic Index (ALI) is linked to higher dementia risk in Latin America. This index, reflecting chronic stress, can help identify cognitive impairment and guide interventions for brain health.

More Related Videos

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

699

Related Experiment Videos

Last Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

699

Area of Science:

  • Neuroscience
  • Public Health
  • Gerontology

Background:

  • Latin America faces health disparities linked to social determinants and low socioeconomic status, increasing dementia risk.
  • Chronic stress may lead to allostatic overload, disrupting physiological systems and elevating dementia risk.
  • Further research is needed to understand cumulative stress effects and develop a population-specific Allostatic Index (ALI).

Purpose of the Study:

  • To investigate the association between an Allostatic Index (ALI) and cognitive impairment in Latin American populations.
  • To develop and validate an ALI specific to diverse Latin American cohorts.
  • To explore the role of chronic stress biomarkers in cognitive decline within the region.

Main Methods:

  • Analysis of data from 8,044 participants across four Latin American cohorts (Chilean National Health Survey, GERO, ReDLat, Costa Rica).
  • Calculation of ALI using metabolic, cardiovascular, immune, neuroendocrine, and anthropometric biomarkers, with cohort-specific indices.
  • Logistic regression models examined the association between ALI and cognitive status using MMSE, MoCA, and CDR assessments.

Main Results:

  • Higher ALI was significantly associated with an increased risk of cognitive impairment and dementia across cohorts.
  • Specific cohort results showed significant associations: Costa Rica (OR=1.048, p=0.021), ReDLat (OR=1.068, p=0.031), GERO Chile (OR=1.17, p=0.04), and CNHS (OR=7.15, p=0.015).
  • The findings indicate a clear link between cumulative physiological stress and cognitive decline in these populations.

Conclusions:

  • The Allostatic Index (ALI) is a valuable marker for identifying cognitive impairment and understanding its connection to chronic stress.
  • Monitoring biomarkers like systolic blood pressure and waist-to-height ratio can enhance dementia characterization in Latin America.
  • Addressing chronic stress and its biological impacts is crucial for mitigating dementia risk in diverse populations.