Related Experiment Video
Updated: Jan 7, 2026
06:05
The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time
Published on: February 19, 2021
1.6K
Appraisal of the references supporting the STOPP/START.version 3 criteria
B Boland1,2, F X Sibille3,4,5, A Mouzon6
1Geriatric Medicine, Cliniques Universitaires Saint-Luc, Brussels, Belgium. Benoit.Boland@uclouvain.be.
European Geriatric Medicine
|December 26, 2025
Summary
The evidence supporting STOPP/START version 3 (SS.v3) criteria was evaluated. Most START criteria have strong evidence, but fewer than half of STOPP criteria require reassessment due to limited high-level evidence.
Area of Science:
- Geriatric Pharmacology
- Evidence-Based Medicine
- Clinical Criteria Development
Background:
- The evidence base for STOPP/START version 3 (SS.v3) criteria is controversial, potentially hindering clinical adoption.
- This study critically appraises the references supporting the SS.v3 criteria.
Purpose of the Study:
- To evaluate the quality and appropriateness of references cited for the 190 SS.v3 criteria.
- To determine the level of evidence supporting each SS.v3 criterion.
Main Methods:
- All 454 references for the 190 SS.v3 criteria were reviewed by geriatric specialists.
- Evidence levels were classified (I-V) based on study design (RCTs, cohort, case-control, etc.).
- References were deemed inappropriate if mismatched, lacking support, or clinically discordant.
Main Results:
- A significant proportion of references (322/454) were reviews (70% STOPP, 71% START).
- High-level evidence (Level I) supported 43% of STOPP criteria and 88% of START criteria.
- 10 criteria (8% of STOPP) lacked appropriate supporting references.
Conclusions:
- Most START criteria are supported by robust evidence, unlike many STOPP criteria.
- A reassessment of STOPP criteria and their supporting literature is necessary.
- Clinicians must consider evidence limitations during shared decision-making with older patients.
Related Concept Videos
01:28Criteria for Causality: Bradford Hill Criteria - II
1.1K
The Bradford Hill criteria serve as guidelines for establishing causative links in epidemiological research. Beyond Strength, Consistency, Specificity, and Temporality, key criteria also include Biological Gradient, Plausibility, Coherence, Experiment, and Analogy. These principles assist scientists in assessing the likelihood of causation in complex biological contexts. Below is a summary of these concepts:
1.1K
01:30Criteria for Causality: Bradford Hill Criteria - I
973
The Bradford Hill criteria are a group of principles that provide a framework to determine a causal relationship between a specific factor and a disease. There are nine criteria that are pivotal in assessing causality in epidemiological studies. Here's a closer look at Strength, Consistency, Specificity, and Temporality criteria with definitions and examples:
973
01:09Decision Making: P-value Method
6.8K
The process of hypothesis testing based on the P-value method includes calculating the P- value using the sample data and interpreting it.
First, a specific claim about the population parameter is proposed. The claim is based on the research question and is stated in a simple form. Further, an opposing statement to the claim is also stated. These statements can act as null and alternative hypotheses: a null hypothesis would be a neutral statement while the alternative hypothesis can...
First, a specific claim about the population parameter is proposed. The claim is based on the research question and is stated in a simple form. Further, an opposing statement to the claim is also stated. These statements can act as null and alternative hypotheses: a null hypothesis would be a neutral statement while the alternative hypothesis can...
6.8K
02:37Restarting Stalled Replication Forks
2.3K
2.3K
01:10Pre-Procedural Guidelines for Assessing Blood Pressure
783
Accurate blood pressure assessment is crucial for diagnosing and managing various health conditions. To ensure the reliability of these measurements, healthcare professionals must adhere to standardized pre-procedural guidelines. These guidelines enhance patient safety and improve the overall quality of healthcare. The following steps are essential for obtaining accurate and consistent blood pressure readings, from using the appropriate tools to ensuring effective communication with the...
783
01:04Significance Testing: Overview
11.5K
Significance testing is a set of statistical methods used to test whether a claim about a parameter is valid. In analytical chemistry, significance testing is used primarily to determine whether the difference between two values comes from determinate or random errors. The effect of a particular change in the measurement protocol, analyst, or sample itself can cause a deviation from the expected result. In the case of a suspected deviation/outlier, we need to be able to confirm mathematically...
11.5K