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Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

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Published on: August 2, 2022

Engineered nanoparticles for endocrine tumor targeting, current progress and future outlook.

Maryam Aftab¹, Zubair Ahmed², Muneeb Ullah³

¹Department of Biosciences, COMSATS University, Park Road 45520, Islamabad, Pakistan.

Medical Oncology (Northwood, London, England)

|December 26, 2025

Summary

Nanotechnology offers new theranostic solutions for endocrine cancers, overcoming treatment challenges like drug resistance and toxicity. Engineered nanoparticles enable precise drug delivery, improving therapeutic outcomes for hormone-secreting tumors.

Keywords:

Endocrine tumors Engineered nanoparticles Nanotechnology Targeting tumors

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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Area of Science:

Endocrinology
Oncology
Nanotechnology
Theranostics

Background:

Endocrine tumors present diagnostic and therapeutic challenges due to complexity, delayed detection, and poor response to conventional treatments.
Tumor heterogeneity, drug resistance, and systemic toxicity limit current therapeutic success.
Nanotechnology offers a novel theranostic approach to enhance drug bioavailability and precision delivery.

Purpose of the Study:

To review the application of nanoparticle-based therapies for endocrine cancers.
To discuss mechanisms of action, targeted delivery strategies, and theranostic applications of nanoparticles.
To explore limitations of current therapies and future prospects of nanoparticle-based treatments for endocrine malignancies.

Main Methods:

Review of engineered nanoparticles (lipid-based, polymeric, inorganic) for targeted endocrine cancer therapy.
Discussion of active targeting (ligand-receptor) and passive accumulation (EPR effect) strategies.
Analysis of nanoparticle mechanisms, including drug resistance mitigation and adaptation to tumor microenvironment.

Main Results:

Nanoparticles enhance drug delivery precision, improving bioavailability and reducing systemic toxicity.
Targeted nanoparticle delivery addresses drug resistance and rapid clearance issues.
Responsive and biomimetic nanoparticles adapt to dynamic tumor microenvironments.

Conclusions:

Nanoparticle-based theranostics represent a promising advancement in endocrine cancer treatment.
Targeted drug delivery via nanoparticles overcomes key limitations of conventional therapies.
Further research into nanoparticle-based therapies holds significant potential for improving patient outcomes in endocrine oncology.