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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Dvir Dori1, Maliha Chowdhury2,3, Nicole D Anderson4,5

  • 1Rotman Research Institute-Baycrest, TORONTO, ON, Canada.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Grip strength normalized by lean body mass (Grip/LBM) is a strong predictor of cognitive performance in older adults. This neuromuscular measure may serve as a practical biomarker for brain neuronal integrity and cognitive health.

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Area of Science:

  • Neurology
  • Gerontology
  • Biomarkers

Background:

  • Cognitive decline in aging is not fully explained by known pathologies like amyloid or tau.
  • Neuronal and synaptic health are critical factors in cognitive function.
  • Maximal grip strength reflects the health of motor units, including neural structures.

Purpose of the Study:

  • To investigate the relationship between grip strength normalized by lean body mass (Grip/LBM) and cognitive performance in older adults.
  • To determine if Grip/LBM is a better predictor of cognition than grip strength or lean body mass alone.
  • To explore Grip/LBM as a potential surrogate marker for brain neuronal integrity.

Main Methods:

  • Assessed 232 older adults (50-95 years) with subjective or mild cognitive impairment.
  • Measured grip strength using a dynamometer and lean body mass via DXA.
  • Evaluated cognitive performance using the Montreal Cognitive Assessment (MoCA) and analyzed associations using correlation and regression.

Main Results:

  • Grip/LBM showed a significant positive correlation with MoCA scores (r=0.286, p < 0.00001).
  • Grip/LBM was a significant predictor of MoCA scores (β=4.69, p=0.001), explaining 22.4% of variance alongside age and sex.
  • Grip strength and lean body mass alone were weaker predictors; the association was stronger in males.

Conclusions:

  • Grip/LBM is a robust predictor of cognitive health, outperforming individual measures of grip strength or lean body mass.
  • Neuromuscular function, indicated by Grip/LBM, may act as a surrogate marker for brain neuronal integrity.
  • Grip/LBM presents potential as a practical biomarker for cognitive health and a target for interventions.